Combined or isolated transplantation of pancreas and kidney at the terminal stage of diabetic nephropathy
نویسندگان
چکیده
منابع مشابه
Histological changes of kidney in diabetic nephropathy
Diabetes mellitus is the most common cause of chronic renal disorders and end-stage kidney disease in developed countries. It is the major cause of dialysis and transplantation. Failure in renal function causes wide disorders in the body. Diabetes results in wide range of alterations in the renal tissue. It is believed that early histological changes in diabetic nephropathy are detectabl...
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For patients with type 1 diabetes, innovations in insulin formulations and delivery have improved the ability to achieve excellent blood glucose control. However, it is uncommon to achieve euglycemia, particularly while avoiding complications arising from hypoglycemia. Pancreas transplantation remains the only broadly applied treatment strategy that can result in normalization of blood glucose,...
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Simultaneous transplantation of kidney and pancreas (SKP) is an excellent treatment option for patients with type I diabetes mellitus with end-stage renal failure. The risk associated with the procedure is somewhat higher than that with transplantation of a kidney alone. This excess risk relates to a higher likelihood of rejection, necessitating on average higher levels of immunosuppression, as...
متن کاملNEPHROLOGY FORUM Combined kidney-pancreas transplantation
A 42-year-woman with a history of juvenile-onset diabetes mellitus was referred to University Hospitals of Cleveland for pancreas transplantation. Diabetes was first diagnosed at age 15, and insulin therapy was begun at that time. At the time of her referral, her serum creatinine concentration was 1.4 mg/dl and the creatinine clearance 80 ml/min. Protein excretion was 1.2 g/24 hrs. Diabetic ret...
متن کاملPrevention of kidney graft diabetic nephropathy by pancreas transplantation in man.
Kidney graft biopsies were performed 2-3 yr after transplantation in eight type I (insulin-dependent) diabetic patients who had previously been subjected to kidney transplantation (six patients) or combined kidney and segmental pancreas transplantation (two patients). In five of the six patients that had undergone only kidney transplantation, light microscopic examination of the graft biopsy re...
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ژورنال
عنوان ژورنال: Diabetes mellitus
سال: 2010
ISSN: 2072-0378,2072-0351
DOI: 10.14341/2072-0351-6062